Time line of inventions..Printing Press..1440 AD.From Wikipaedia.

The 15th century invention of the printing press with movable type by the GermanJohannes Gutenberg is widely regarded as the most influential event of the modern era.^[1]

A printing press is a device for applying pressure to an inked surface resting upon a print medium (such as paper or cloth), thereby transferring the ink. Typically used for texts, the invention and spread of the printing press are widely regarded as the most influential events in the second millennium AD,^[1] revolutionizing the way people conceive and describe the world they live in, and ushering in the period of modernity.^[2]

The printing press was invented in the Holy Roman Empire by the German Johannes Gutenberg in around 1440, based on existing screw presses. Gutenberg, agoldsmith by profession, developed a complete printing system, which perfected the printing process through all of its stages by adapting existing technologies to printing purposes, as well as making groundbreaking inventions of his own. His newly devised hand mould made for the first time possible the precise and rapid creation of metal movable type in large quantities, a key element in the profitability of the whole printing enterprise.

Facts that you may not know..Interesting though.

Nobel Prize in 2008 n Medicine..AIDS Virus and Cervical cancer discovered..

Discoverers of AIDS and Cancer Viruses Win Nobel

From left, Dr. Harald zur Hausen, 72, of Germany, and French virologists Dr. Françoise Barré-Sinoussi, 61, and Dr. Luc Montagnier, 76.

By LAWRENCE K. ALTMAN

Published: October 7, 2008

The Nobel Prize in Medicine was awarded Monday to three European scientists who had discovered viruses behind two devastating illnesses,AIDS and cervical cancer.

Half of the award will be shared by two French virologists, Françoise Barré-Sinoussi, 61, and Luc A. Montagnier, 76, for discovering H.I.V., the virus that causes AIDS. Conspicuously omitted was Dr. Robert C. Gallo, an American virologist who vied with the French team in a long, often acrimonious dispute over credit for the discovery of H.I.V.

The other half of the $1.4 million award will go to a German physician-scientist, Dr. Harald zur Hausen, 72, for his discovery of H.P.V., or the human papilloma virus. Dr. zur Hausen of the German Cancer Research Center in Heidelberg “went against current dogma” by postulating that the virus caused cervical cancer, said the Karolinska Institute in Stockholm, which selects the medical winners of the prize, formally called the Nobel Prize in Physiology or Medicine.

His discovery led to the development of two vaccines against cervical cancer, the second most common cancer among women. An estimated 250,000 women die of cervical cancer each year, mostly in poor countries.

This year’s Nobel Prize-winning research focused on two viruses that take many years to cause damage. Much of the research was carried out a quarter of a century or more ago.

Since its discovery in 1981, AIDS has rivaled the worst epidemics in history. An estimated 25 million people have died, and 33 million more are living with H.I.V.

In 1983, Dr. Montagnier and Dr. Barré-Sinoussi, a member of his lab at the Pasteur Institute in Paris, published their report of a newly identified virus. The Karolinska Institute said that discovery led to blood tests to detect the infection and to anti-retroviral drugs that can prolong the lives of patients. The tests are now used to screen blood donations, making the blood supply safer for transfusions and blood products.

The viral discovery has also led to an understanding of the natural history of H.I.V. infection in people, which ultimately leads to AIDS and death unless treated.

H.I.V. is a member of the lentivirus family of viruses. The French scientists were cited for identifying a virus they called L.A.V. (now known as H.I.V.) in lymph nodes from early and late stages of the infection.

“Never before has science and medicine been so quick to discover, identify the origin and provide treatment for a new disease entity,” the Karolinska Institute said.

Reached by the Nobel committee in Abidjan, Ivory Coast, where he is attending an international AIDS conference, Dr. Montagnier said, “The fight is not finished” and he was now working on a way to eradicate H.I.V. in those already infected. Dr. Montagnier now works at the World Foundation for AIDS Research and Prevention in Paris. For a brief time in the late 1990s, he worked at Queens College in New York City.

Nobel Foundation rules limit the number of recipients of its medical prizes to a maximum of three each year, and omissions often create controversy.

The dispute between Dr. Gallo and the French team spanned years and sprawled from the lab into the highest levels of government. Dr. Gallo, 71, now at the University of Marylandin Baltimore, worked for many years at the National Cancer Institute in Bethesda, Md.

While in Bethesda in 1984, a year after the French team’s report, Dr. Gallo reported finding a virus that he called H.T.L.V.-3 and that was later shown to be nearly identical to the French L.A.V. After additional studies, Dr. Gallo said cultures in his laboratory had accidentally become contaminated with the French virus.

In 1986, Dr. Gallo and Dr. Montagnier shared a prestigious Lasker award, given in the United States; Dr. Montagnier was cited for discovering the virus and Dr. Gallo for determining that it caused AIDS.

In 1987, President Reagan and Prime Minister Jacques Chirac of France signed an agreement to share royalties and credit for the discovery.

But Maria Masucci, a member of the Nobel Assembly, told Reuters on Monday that “there was no doubt as to who made the fundamental discoveries.”

Dr. Gallo told The Associated Press on Monday that it was “a disappointment” not to have been honored with the French team. Later, Dr. Gallo issued a statement congratulating this year’s Nobel Prize winners and said he “was gratified to read Dr. Montagnier’s kind statement this morning expressing that I was equally deserving.”

Dr. John E. Niederhuber, the director of the National Cancer Institute, said Monday that Dr. Gallo “was instrumental in every major aspect of the discovery of the AIDS virus. Dr. Gallo discovered interleukein-2 (Il-2), an immune system signaling molecule, which was necessary for the discovery of the AIDS virus, serving as a co-culture factor that allowed the virus to grow. Numerous scientific journal articles, many co-authored by Dr. Gallo and Dr. Montagnier, cite the two scientists as co-discoverers of the AIDS virus.”

Dr. Anthony S. Fauci, a virologist and immunologist who directs the National Institute of Allergy and Infectious Diseases, said in an interview, “The committee has a long history of awarding the prize to the person or group that makes the first seminal observation or discovery, and they did that in this case.” He added, “Nobel Prizes are always associated with great joy and great sadness, depending on who wins and who you are.”

The link between human papilloma virus and cervical cancer took years to gain acceptance. When Dr. zur Hausen proposed the connection in the 1970s, infection with papilloma virus was thought to cause nothing more serious than common warts, and the prevailing scientific view was that herpes type 2 virus caused cervical cancer. But Dr. zur Hausen consistently failed to find herpes type 2 DNA in cervical cancer cells using the newer molecular biology laboratory techniques.

In the 1980s, an American researcher said that financing agencies in the United States had rejected as unpromising his grant proposals to study links between papilloma viruses and cancer. The National Institutes of Health did not reply on Monday to questions about such proposals.

In 1983, Dr. zur Hausen discovered the first H.P.V., type 16, among biopsies of women who had cervical cancer. He went on to show that more than one H.P.V. type could lead to cervical cancer, in part by cloning H.P.V. 16 and another type, 18. Further research has shown that the two H.P.V. types are consistently found in about 70 percent of cervical cancer biopsies throughout the world, the institute said.

Of the more than 100 human papilloma viruses now known, about 40 infect the genital tract and 15 of them put women at high risk for cervical cancer. But in a vast majority of cases, the body’s immune system clears H.P.V. before the viruses cause harm. It is chronic infection that is dangerous.

H.P.V. viruses account for more than 5 percent of all cancers worldwide. Some types of H.P.V. are found in cancers of the vulva, penis, mouth and other areas. Other H.P.V. viruses cause warts on the foot and elsewhere.

Dr. zur Hausen’s research has led to development of vaccines that protect against strains of H.P.V. that cause most cases of cervical cancers. However, controversy has arisen over who should get the vaccines.

The United States Food and Drug Administration has approved one papilloma virus vaccine, Gardasil, for girls and women ages 9 to 26 and with advice that they get immunized before sexual activity begins. Because the vaccine was developed recently, doctors do not know for how long it will last.

Copernicus.

The 16th century was a time of unprecedented change, the very beginning of the modern era of science, a time of great exploration, religious and political urmoil, and extraordinary literature.

In 1543, Copernicus published his theory that the Earth was not the center of the universe, rather, the Earth and the other planets orbited around the Sun. Called the Copernican Revolution, his theory forever changed astronomy, and ultimately changed all of science.

During 16th century, advancements were made in the theories of mathematics, cosmography, geography and natural history. 16th century inventions related to the fields of engineering, mining, navigation and the military arts were prominent.

NobelPrize winners in Medicine..2009

Photo: U. Montan

Photo: U. Montan

Photo: U. Montan

Elizabeth H. Blackburn

The Nobel Prize in Physiology or Medicine 2009

jointly to

Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak

for the discovery of

"how chromosomes are protected

by telomeres and the enzyme telomerase"

 

Summary

This year's Nobel Prize in Physiology or Medicine is awarded to three scientists who have solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation. The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes – the telomeres – and in an enzyme that forms them – telomerase.

The long, thread-like DNA molecules that carry our genes are packed into chromosomes, the telomeres being the caps on their ends. Elizabeth Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation. Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase.

If the telomeres are shortened, cells age. Conversely, if telomerase activity is high, telomere length is maintained, and cellular senescence is delayed. This is the case in cancer cells, which can be considered to have eternal life. Certain inherited diseases, in contrast, are characterized by a defective telomerase, resulting in damaged cells. The award of the Nobel Prize recognizes the discovery of a fundamental mechanism in the cell, a discovery that has stimulated the development of new therapeutic strategies.

The mysterious telomere

The chromosomes contain our genome in their DNA molecules. As early as the 1930s,Hermann Muller (Nobel Prize 1946) and Barbara McClintock (Nobel Prize 1983) had observed that the structures at the ends of the chromosomes, the so-called telomeres, seemed to prevent the chromosomes from attaching to each other. They suspected that the telomeres could have a protective role, but how they operate remained an enigma.

When scientists began to understand how genes are copied, in the 1950s, another problem presented itself. When a cell is about to divide, the DNA molecules, which contain the four bases that form the genetic code, are copied, base by base, by DNA polymerase enzymes. However, for one of the two DNA strands, a problem exists in that the very end of the strand cannot be copied. Therefore, the chromosomes should be shortened every time a cell divides – but in fact that is not usually the case (Fig 1).

Both these problems were solved when this year's Nobel Laureates discovered how the telomere functions and found the enzyme that copies it.

Telomere DNA protects the chromosomes

In the early phase of her research career, Elizabeth Blackburn mapped DNA sequences. When studying the chromosomes of Tetrahymena, a unicellular ciliate organism, she identified a DNA sequence that was repeated several times at the ends of the chromosomes. The function of this sequence, CCCCAA, was unclear. At the same time, Jack Szostak had made the observation that a linear DNA molecule, a type of minichromosome, is rapidly degraded when introduced into yeast cells.

Blackburn presented her results at a conference in 1980. They caught Jack Szostak's interest and he and Blackburn decided to perform an experiment that would cross the boundaries between very distant species (Fig 2). From the DNA of Tetrahymena, Blackburn isolated the CCCCAA sequence. Szostak coupled it to the minichromosomes and put them back into yeast cells. The results, which were published in 1982, were striking – the telomere DNA sequence protected the minichromosomes from degradation. As telomere DNA from one organism,Tetrahymena, protected chromosomes in an entirely different one, yeast, this demonstrated the existence of a previously unrecognized fundamental mechanism. Later on, it became evident that telomere DNA with its characteristic sequence is present in most plants and animals, from amoeba to man.

An enzyme that builds telomeres

Carol Greider, then a graduate student, and her supervisor Blackburn started to investigate if the formation of telomere DNA could be due to an unknown enzyme. On Christmas Day, 1984, Greider discovered signs of enzymatic activity in a cell extract. Greider and Blackburn named the enzyme telomerase, purified it, and showed that it consists of RNA as well as protein (Fig 3). The RNA component turned out to contain the CCCCAA sequence. It serves as the template when the telomere is built, while the protein component is required for the construction work, i.e. the enzymatic activity. Telomerase extends telomere DNA, providing a platform that enables DNA polymerases to copy the entire length of the chromosome without missing the very end portion.

Telomeres delay ageing of the cell

Scientists now began to investigate what roles the telomere might play in the cell. Szostak's group identified yeast cells with mutations that led to a gradual shortening of the telomeres. Such cells grew poorly and eventually stopped dividing. Blackburn and her co-workers made mutations in the RNA of the telomerase and observed similar effects in Tetrahymena. In both cases, this led to premature cellular ageing – senescence. In contrast, functional telomeres instead prevent chromosomal damage and delay cellular senescence. Later on, Greider's group showed that the senescence of human cells is also delayed by telomerase. Research in this area has been intense and it is now known that the DNA sequence in the telomere attracts proteins that form a protective cap around the fragile ends of the DNA strands.

An important piece in the puzzle – human ageing, cancer, and stem cells

These discoveries had a major impact within the scientific community. Many scientists speculated that telomere shortening could be the reason for ageing, not only in the individual cells but also in the organism as a whole. But the ageing process has turned out to be complex and it is now thought to depend on several different factors, the telomere being one of them. Research in this area remains intense.

Most normal cells do not divide frequently, therefore their chromosomes are not at risk of shortening and they do not require high telomerase activity. In contrast, cancer cells have the ability to divide infinitely and yet preserve their telomeres. How do they escape cellular senescence? One explanation became apparent with the finding that cancer cells often have increased telomerase activity. It was therefore proposed that cancer might be treated by eradicating telomerase. Several studies are underway in this area, including clinical trials evaluating vaccines directed against cells with elevated telomerase activity. 

Some inherited diseases are now known to be caused by telomerase defects, including certain forms of congenital aplastic anemia, in which insufficient cell divisions in the stem cells of the bone marrow lead to severe anemia. Certain inherited diseases of the skin and the lungs are also caused by telomerase defects.

In conclusion, the discoveries by Blackburn, Greider and Szostak have added a new dimension to our understanding of the cell, shed light on disease mechanisms, and stimulated the development of potential new therapies.

Carol W. Greider

Jack W. Szostak

WHAT IS HOMOGENISED MILK?

What is homogenization and does it detract from the healthfulness of milk?

With the first sale of homogenized milk occurring in the state of Connecticut in 1919, U.S. consumers have become accustomed to milk in a physical state very different from its natural one. Natural milk is an oil-in-water emulsion, and like all emulsions, milk is unstable; if left to sit over time, its oil (fat) portion will rise to the top of its water portion and form a cream layer. The formation of a cream layer at the top of the milk would occur in all of our store-bought milk if the milk were not homogenized.

The process of homogenization, where milk is passed through a valve under high pressure, breaks apart milk's fat into much smaller droplets only 0.2 to 2 microns in size. Unlike the larger, natural fat droplets found in milk, these pressure-created micro-droplets will stay dispersed, creating the more "cohesive" texture we are used to in milk.

Beginning in the 1960's and continuing through the 1980's, an M.D. named Kurt Oster published a series of articles questioning the health safety of homogenized milk and hypothesized a connection between homogenization and the development of heart disease. According to Oster's hypothesis, an enzyme called xanthine oxidase (XO) was naturally associated with the fat globules in milk. He theorized that homogenization trapped XO in the new micro-droplets and prevented this enzyme from being metabolized in the digestive tract. Oster was convinced that because of homogenization unmetabolized XO was being absorbed from the digestive tract into the bloodstream where it could trigger immune reactions and cause damage to blood vessel walls. The result was described as plaque formation-the very same plaque formation that gives rise to atherosclerosis in many adults.

Research studies have yet to conclusively prove or disprove Oster's hypothesis. There continues to be strong interest in XO, however, and its relationship to heart problems. But the contribution of homogenization to these problems is still a research hypothesis and not a research conclusion.

For those who are looking for alternatives to homogenized milk, nonhomogenized cow's milk is becoming increasingly available in the U.S. Additionally, goat's milk may be of interest since it often requires no homogenization because its fat droplets are smaller to begin with and remain better dispersed in the liquid portion of the milk. I support the consumption of these nonhomogenized forms of milk, even though I have not seen research that confirms the connection between homogenization and risk of heart disease, or the mechanism of XO damage.

In the absence of better research, it's impossible for me to take a stand against the consumption of homogenized milk for health reasons. Yet, I recognize the more natural composition of nonhomogenized milk, and I support its availability and consumption since homogenization is a processing step that takes us away from the natural form of whole milk. It's one that's carried out for convenience and texture, not for nourishment or safety.

Facts oabout the Facebook.

1) 1 in every 13 people on Earth is on Facebook.
2) 85%+ of all college students use FACEBOOK and 70% of them log in EVERYDAY.

3) People spend over 700 billion minutes per month on Facebook
4) Psychologists have introduced a diagnosis FAD (Facebook Addiction Disorder) as a new kind of addiction
5) More than 60 % of men and women have used Facebook to stalk their ex.
6) In 1 hour 3,000,000 links are shared on Facebook.
7) In 1 hour 4,452,000 event invites are posted.
8) In 1 hour 3,969,000 photos are tagged.
9) In 1 hour 5,553,000 status updates are entered.
10) In 1 hour 6 million friend requests are accepted.
11) In 1 hour 8,148,000 photos are uploaded.
12) In 1 hour 8,148,000 messages are sent.
13) In 1 hour 31 million comments are posted.
14) In 1 hour 4,761,000 wall posts are written.
15) No doubt, Facebook Founder Mark Zuckerberg is going to reap billions from this IPO. But his salary is set to drop. Currently, he makes a base salary of $500,000 per year. But at his request his annual salary will be set to $1 as of January 1, 2013.
16) Facebook links about sex are shared 90% more than average.
17) Facebook was almost shut down by a lawsuit by ConnectU who claimed that Zuckerburg stole the idea and Technology for Facebook (the issue was settled out of court).
18) According to a research, people in Facebook relationships are happier than single people.
19) Over 25% of users have already been dumped via Facebook.
20) Facebook causes 1 in 5 Divorces.
21) 36% of users check Facebook, Twitter or texts after sex.
22) People that use Facebook on their mobile devices are twice as active on Facebook than non-mobile users.
23) In 2008, a 23-year-old woman named Lauren Michaels created a group titled “I Need Sex” on Facebook. Within 10 minutes, she had 35 members and soon attracted 100—50 of whom she eventually slept with. Facebook has since removed her page.
24) A 39-year-old Pennsylvania father was arrested for openly asking his 13-year-old daughter for sex over Facebook.
25) The first person to invest in Facebook was the cofounder of PayPal, Peter Thiel, who invested $500,000 in June 2004.

2010 Robert G. Edwards Nobel Prize winner in 2010

Medicine Nobel Prize 2010 Winner: Robert Edwards

British scientist, Robert G. Edwards has been awarded this year's Nobel prize in Medicine or Physiology for the development of human in vitro fertilization (IVF) therapy. The decision to honour him with the Nobel prize was disclosed on Monday by the Nobel Assembly at Karolinska Institutet of Stockholm, Sweden for his achievements that made it possible to treat infertility, a medical condition afflicting a large proportion of humanity including more than 10% of all couples worldwide.

As early as the 1950s, Edwards had the vision that IVF could be useful as a treatment for infertility. He worked systematically to realize his goal, discovered important principles for human fertilization, and succeeded in accomplishing fertilization of human egg cells in test tubes (or more precisely, cell culture dishes). His efforts were finally crowned by success on 25 July, 1978, when the world's first "test tube baby" was born. During the following years, Edwards and his co-workers refined IVF technology and shared it with colleagues around the world.

Approximately four million individuals have so far been born following IVF. Many of them are now adult and some have already become parents. A new field of medicine has emerged, with Robert Edwards leading the process all the way from the fundamental discoveries to the current, successful IVF therapy. His contributions represent a milestone in the development of modern medicine.

Infertility – a medical and psychological problem: More than 10% of all couples worldwide are infertile. For many of them, this is a great disappointment and for some causes lifelong psychological trauma. Medicine has had limited opportunities to help these individuals in the past. Today, the situation is entirely different. In vitro fertilization (IVF) is an established therapy when sperm and egg cannot meet inside the body.

Basic research bears fruit: The British scientist Robert Edwards began his fundamental research on the biology of fertilization in the 1950s. He soon realized that fertilization outside the body could represent a possible treatment of infertility. Other scientists had shown that egg cells from rabbits could be fertilized in test tubes when sperm was added, giving rise to offspring. Edwards decided to investigate if similar methods could be used to fertilize human egg cells.

It turned out that human eggs have an entirely different life cycle than those of rabbits. In a series of experimental studies conducted together with several different co-workers, Edwards made a number of fundamental discoveries. He clarified how human eggs mature, how different hormones regulate their maturation, and at which time point the eggs are susceptible to the fertilizing sperm. He also determined the conditions under which sperm is activated and has the capacity to fertilize the egg. In 1969, his efforts met with success when, for the first time, a human egg was fertilized in a test tube.

In spite of this success, a major problem remained. The fertilized egg did not develop beyond a single cell division. Edwards suspected that eggs that had matured in the ovaries before they were removed for IVF would function better, and looked for possible ways to obtain such eggs in a safe way.

From experiment to clinical medicine: Edwards contacted the gynecologist Patrick Steptoe. He became the clinician who, together with Edwards, developed IVF from experiment to practical medicine. Steptoe was one of the pioneers in laparoscopy, a technique that was new and controversial at the time. It allows inspection of the ovaries through an optical instrument. Steptoe used the laparoscope to remove eggs from the ovaries and Edwards put the eggs in cell culture and added sperm. The fertilized egg cells now divided several times and formed early embryos, 8 cells in size (see figure).

These early studies were promising but the Medical Research Council decided not to fund a continuation of the project. However, a private donation allowed the work to continue. The research also became the topic of a lively ethical debate that was initiated by Edwards himself. Several religious leaders, ethicists, and scientists demanded that the project be stopped, while others gave it their support.

The birth of Louise Brown - a historic event: Edwards and Steptoe could continue their research thanks to the new donation. By analyzing the patients' hormone levels, they could determine the best time point for fertilization and maximize the chances for success. In 1978, Lesley and John Brown came to the clinic after nine years of failed attempts to have a child. IVF treatment was carried out, and when the fertilized egg had developed into an embryo with 8 cells, it was returned to Mrs. Brown. A healthy baby, Louise Brown, was born through Caesarian section after a full-term pregnancy, on 25 July, 1978. IVF had moved from vision to reality and a new era in medicine had begun.

IVF is refined and spreads around the world: Edwards and Steptoe established the Bourn Hall Clinic in Cambridge, the world's first centre for IVF therapy. Steptoe was its medical director until his death in 1988, and Edwards was its head of research until his retirement. Gynecologists and cell biologists from all around the world trained at Bourn Hall, where the methods of IVF were continuously refined. By 1986, 1,000 children had already been born following IVF at Bourn Hall, representing approximately half of all children born after IVF in the world at that time.

Today, IVF is an established therapy throughout the world. It has undergone several important improvements. For example, single sperm can be microinjected directly into the egg cell in the culture dish. This method has improved the treatment of male infertility by IVF. Furthermore, mature eggs suitable for IVF can be identified by ultrasound and removed with a fine syringe rather than through the laparoscope.

IVF is a safe and effective therapy. 20-30% of fertilized eggs lead to the birth of a child. Complications include premature births but are very rare, particularly when one egg only is inserted into the mother. Long-term follow-up studies have shown that IVF children are as healthy as other children.

Approximately four million individuals have been born thanks to IVF. Louise Brown and several other IVF children have given birth to children themselves; this is probably the best evidence for the safety and success of IVF therapy. Today, Robert Edwards' vision is a reality and brings joy to infertile people all over the world.

Biography: Robert G. Edwards was born in 1925 in Manchester, England. After military service in the Second World War, he studied biology at the University of Wales in Bangor and at Edinburgh University in Scotland, where he received his PhD in 1955 with a Thesis on embryonal development in mice. He became a staff scientist at the National Institute for Medical Research in London in 1958 and initiated his research on the human fertilization process. From 1963, Edwards worked in Cambridge, first at its university and later at Bourn Hall Clinic, the world's first IVF centre, which he founded together with Patrick Steptoe. Edwards was its research director for many years and he was also the editor of several leading scientific journals in the area of fertilization. Robert Edwards is currently professor emeritus at the University of Cambridge.

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